Table 2.

Effects of meldonium administration on the dimensions of the left ventricle. Treatment with meldonium restored the systolic dimensions of the left ventricle after the injection of lipopolysaccharide (LPS).

	Control	LPS	LPS + Meldonium
IVSs, mm	1.1 ± 0.03 *	1.0 ± 0.03	1.1 ± 0.02 *
IVSd, mm	0.6 ± 0.02	0.5 ± 0.01	0.6 ± 0.02
LVPWs, mm	1.1 ± 0.04 *	0.8 ± 0.03	1.0 ± 0.04 #
LVPWd, mm	0.6 ± 0.04	0.5 ± 0.03	0.5 ± 0.02
LVIDs, mm	3.2 ± 0.1 *	3.6 ± 0.1	3.2 ± 0.1 *
LVIDd, mm	4.6 ± 0.1	4.5 ± 0.1	4.3 ± 0.1
ESV, mL	0.09 ± 0.01 *	0.11 ± 0.01	0.09 ± 0.01 *
EDV, mL	0.25 ± 0.02	0.23 ± 0.02	0.21 ± 0.01
HR, bpm	453 ± 27	501 ± 11	477 ± 10

Heart rate (HR), left ventricular posterior wall thickness at end-systole (LVPWs), left ventricular posterior wall thickness at end-diastole (LVPWd), interventricular septal thickness at end-systole (IVSs), interventricular septal thickness at end-diastole (IVSd), left ventricular internal dimension at end-systole (LVIDs), left ventricular internal dimension at end-diastole (LVIDd), end systolic volume (ESV) and end diastolic volume (EDV) of the animals from all three groups. The data are shown as the mean±SEM of 7 to 8 animals. # p < 0.07 vs. the LPS group, one-way ANOVA with Dunnett’s multiple comparison test, * p < 0.05 vs. the LPS group, one-way ANOVA with Dunnett’s multiple comparison test.