Fig. 2.

Validation of LPS-moiety requirements for Salmonella phages (a) Overview of O5 S. Typhimurium LPS and O-antigen biosynthesis. The four sugars in brackets comprise the O-antigen, which repeats 16–35 times per LPS molecule under standard growth conditions. Key for non-essential LPS and O-antigen precursor biosynthesis genes are described to the right. Genes covered in our library and used for analysis are written in black. Genes not covered in our library, and thus not analysed in this study are written in orange. (b) Infectivity matrix using a previously established Salmonella LPS panel (Table S5). The identity of the LPS chemotype corresponding to specific mutation is presented in (a). sm stands for smooth-LPS chemotype. Data for this figure is aggregated from Figs S5–S11, S13–S15 and S17.