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. Author manuscript; available in PMC: 2022 Jan 10.
Published in final edited form as: Eur J Immunol. 2021 Sep 16;51(10):2441–2451. doi: 10.1002/eji.202049150

Figure 4. AP-4-287 repressed Ki67+ CD4+ T cells in the GC and trended to lower Tfh precursor cells in SRBC-vaccinated mice.

Figure 4.

(A) Representative flow plot showing AP-4-287 reduced Ki67+CD4+ T cells in SRBC-vaccinated mice. (B) AP-4-287 reduced the frequency of Ki67+CD4+ T cells in a dose-dependent manner. (C) Representative IHC images (4x magnification) showing AP-4-287 reduced Ki67+CD4+ cells in the GC of spleen from SRBC-vaccinated mice. (D) Gating strategy for analyzing CXCR5−PD1dimTfh precursor CD4+ T cells. (E) AP-4-287 trended to reduce Tfh precursor CD4+ T in a dose-dependent manner. Welch-test was performed to compare the results between two groups. * p<0.05; ** p<0.01. All data are from 2–3 independent experiments with 3–5 mice per experiment.