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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: J Neurosci Methods. 2020 Nov 28;348:109015. doi: 10.1016/j.jneumeth.2020.109015

Table 1.

Microendoscopy system features

Feature Fiber Photometry Single-photon Imaging Two-photon Imaging
Resolution Population dynamics, no single-cell resolution Cellular resolution, overlapping cells in Z-space Subcellular resolution, optical sectioning
Restraint Freely moving Freely moving Typically head-fixed; freely moving not widely available
Motion Correction Second channel used to remove motion artifacts Required Required
Skill required + ++ +++
Footprint Small Moderate, dual-site imaging possible Large
Cost $ $$ − $$$ $$$$