Table 1.
Summary of clinicopathological characteristics before and after the index biopsy for women with normal and CIN3/AIS biopsies (n = 27). The number of cases in each group is given followed by a percentage for each group in parenthesis.
| Normal Biopsies n = 14 (%) |
CIN3/AIS Biopsies n = 13 (%) |
p-Value | |
|---|---|---|---|
| Cytology results before index biopsy | 0.005 *** | ||
| 1 NILM | 9 (100) | 0 (0) | |
| 2 ASC-US | 1 (50) | 1 (50) | |
| 3 LSIL | 2 (50) | 2 (50) | |
| 4 HSIL | 1 (13) | 7 (87) | |
| 5 ASC-H | 1 (33) | 2 (67) | |
| HPV result/genotype before index biopsy * | 0.045 *** | ||
| 6 HPV16 | 5 (45) | 6 (55) | |
| HPV18 | 0 (0) | 3 (100) | |
| non 16/18 hrHPV | 9 (82) | 2 (18) | |
| HPV result/genotype in index biopsy | 0.056 *** | ||
| HPV16 | 7 (47) | 8 (53) | |
| HPV18 | 0 (0) | 3 (100) | |
| non 16/18 hrHPV | 2 (50) | 2 (50) | |
| HPV negative | 5 (100) | 0 (0) | |
| Cone excision | <0.001 *** | ||
| Yes | 4 (24) | 13 (76) | |
| No | 10 (100) | 0 (0) | |
| Histology results of cone excision | 0.001 *** | ||
| normal | 2 (100) | 0 (0) | |
| 7 CIN1 | 2 (100) | 0 (0) | |
| CIN3 | 0 (0) | 11 (100) | |
| 8 AIS | 0 (0) | 2 (100) | |
| Cytology result after index biopsy ** | 0.039 *** | ||
| Inadequate | 1 (100) | 0 (0) | |
| NILM | 8 (38) | 13 (62) | |
| ASC-US | 3 (100) | 0 (0) | |
| HSIL | 1 (100) | 0 (0) | |
| 9 NA | 1 (100) | 0 (0) | |
| HPV result/genotype after index biopsy ** | 0.288 *** | ||
| HPV16 | 1 (50) | 1 (50) | |
| HPV18 | 0 (-) | 0 (-) | |
| non 16/18 hrHPV | 6 (75) | 2 (25) | |
| HPV negative | 6 (38) | 10 (62) | |
| NA | 1 (100) | 0 (0) | |
| Median age at diagnosis (range) | 33 (26–48) | 34 (28–51) | 0.367 **** |
| Median HPV Persistency (days) LBC—last HPV test (range) | 1225 (474–2199) | 351 (38–1136) | <0.001 **** |
| Median Total Follow-up (days) from first LBC to last cervical sample within the follow-up period (range) | 1336 (717–2199) | 985 (414–2072) | 0.019 **** |
* two LBC samples were not HPV-tested, but HPV16 positive in the index biopsy. ** if several cytology/HPV tests are performed, the result on the last sample is reported. *** Fisher Exact test. **** Mann-Whitney U-test. 1 Negative for intraepithelial lesions or malignancy (NILM). 2 Atypical squamous cells of undetermined significance (ASCUS). 3 Low-grade squamous intraepithelial lesion (LSIL). 4 High grade squamous intraepithelial lesions (HSIL). 5 Atypical squamous cells, cannot exclude a high-grade lesion (ASC-H). 6 Human Papilloma Virus (HPV). 7 Cervical intraepithelial neoplasia (CIN). 8 Adenocarcinoma in situ (AIS). 9 Not Applicable (NA).