Table 2.

Role of miR-149-5p or miR-149-5p-intercating genes in the carcinogenesis based on animal models (∆: knock-down or deletion, ↑: up-regulation or enhancement, ↓: down-regulation, CDDP: cisplatin, UA: ursolic acid, PTX: Paclitaxel).

Tumor Type	Animal Models	Results	Reference
Gastric cancer	BALB/c nude mice	∆ circNRIP1 (which sponges miR-149-5p): ↓ tumor volume, ↓ tumor weight	[6]
	female BALB/c nude mice	∆ BLACAT1 (which sponges miR-149-5p): ↓ tumor volume, ↓ tumor weight	[7]
	male BALB/C nude mice	∆ circNHSL1 (which sponges miR-149-5p): ↓ tumor volume, ↓ tumor weight	[8]
Colorectal cancer	BALB/c nude mice	∆ LINC00460 (which sponges miR-149-5p): ↓ tumor volume, ↓ tumor weight	[9]
	female BALB/c nude mice	↑ circCTNNA1 (which sponges miR-149-5p): ↑tumor volume, ↑tumor weight	[11]
	female nude mice	∆ DLGAP1-AS1 (which sponges miR-149-5p): ↓tumor growth, ↑5-FU sensitivity	[13]
	male BALB/C nude mice	∆ circ5615 (which sponges miR-149-5p): ↓ tumor growth	[14]
	athymic male mice	∆ LINC00460 (which sponges miR-149-5p): ↓tumor volume, ↓tumor weight	[40]
Papillary thyroid cancer	male nude mice	∆ circ-FLNA (which sponges miR-149-5p): ↓tumor growth, ↓tumor volume, ↓ metastasis	[16]
Ovarian cancer	BALB/c-nu mice	∆ miR-149-5p: ↓ tumor volume, ↓ tumor weight, ↓ resistance to CDDP	[19]
Breast cancer	female BALB/c nude mice	∆ circ_0072995: ↓ tumor volume, ↓ tumor weight	[22]
	female athymic mice	∆ miR-149-5p: ↓ ability of propofol to inhibit lung metastasis	[23]
	female athymic nude mice	UA and PTX treatment: ↓tumor volume, ↓ tumor weight	[24]
Lung cancer	BALB/c nude mice	∆ B3GNT3: ↓ tumor volume, ↓ tumor weight	[27]
	female BALB/c nude mice	∆ HNF1A- AS1: ↓ tumor volume, ↓ tumor weight	[29]
	female BALB/c nude mice	∆ MIAT: ↓ tumor volume, ↓ tumor weight	[30]
	athymic BALB/c mice	∆ HOTAIR: ↓ tumor volume, ↓ tumor weight, ↓ DDP resistance	[31]
Hepatocellular carcinoma	nude mice	↑ macrophages (THP-1): ↑ metastasis miR-149-5p: ↓ metastasis	[35]
	nude mice	∆ SNHG8: ↓ tumor volume, ↓ tumor weight, ↓ metastasis	[41]
Esophageal squamous cell cancer	male BALB/c athymic nude mice	∆ circ_0000654: ↓ tumor volume, ↓ tumor weight, ↓ metastasis	[39]
Acute lymphocytic leukemia	BALB/c nude mice	↑ circADD2: ↓ tumor volume, ↓ tumor weight	[48]