Table 3.
Summary of prognostic biomarkers for acute peripheral facial palsy (Hemostatic parameter).
| Author (Year) | Study Design | Sample Size | Age (years) | Biomarkers | Results/Conclusions |
|---|---|---|---|---|---|
| Cayir et al. (2021) [17] | Retrospective | 59 patients, 65 controls |
10.69 ± 5.76, 10.87 ± 3.22 (Mean) |
MPV, Hbg, RDW | High NLR and CAR values in pediatric BP may be related to poor prognosis in such patients. CAR, however, is a more valuable parameter than NLR in terms of indicating poor prognosis |
| Baklacı et al. (2020) [19] | Retrospective | 76 patients, 60 controls |
39.76 ± 9.02, 39.31 ± 8.16 (Mean) | MPV | Mean LDH concentrations and NLR were significantly high in BP group than in control group |
| Cayir et al. (2020) [20] | Retrospective, archival, cross-sectional study | 79 patients (23 non recovery group patients, 56 recovery group patients), 60 controls | 49 ± 3 (Non recovery), 49 ± 3 (Recovery), 50 ± 3 (Controls) | Platelet, Hbg | Higher CAR and NLR were associated with poor prognosis in BP. CAR might be the most significant indicator of poor prognosis in BP |
| Kınar et al. (2020) [21] | Retrospective | 88 patients, 50 controls |
54, 47 (Mean) |
Platelet | Patient group had higher neutrophil counts and higher SII and NLR values than the control group. Among BP patients, the SII values of the unrecovered group were statistically higher than those of the recovered group |
| Aysel et al. (2020) [22] | Retrospective | 47 patients | 14.7 ± 2.5 | MPV | NLR in patients with advanced grades (grade 4, 5, 6) was higher, compared to that of patients with grade 2 and 3. NLR at admission can be considered as a prognostic factor |
| Kim et al. (2020) [24] | Retrospective | 54 patients, 39 controls |
14.5 ± 4.1, 11.9 ± 5.2 (Mean) |
MPV, RDW | The NLR and PLR values in the BP group were significantly higher than in the control group. However, there were no significant differences between the low-grade and high-grade BP groups nor were there any statically significant differences in the other characteristics. |
| Kim et al. (2019) [25] | Retrospective | 51 patients | 39.7 ± 20.1 (Mean) | Platelet | NLR was significantly higher in patients with severe than with mild to moderate palsy. Recovery time was significantly longer in patients with high NLR than low NLR |
| Ulusoy et al. (2018) [28] | Prospective | 24 patients, 29 controls |
45.12 ± 12.34, 44.34 ± 9.97 (Mean) |
PDW, platelet | There was no correlation between the NLR value and the prognosis of Bell’s Palsy. A comparison of the recovered and unrecovered patients revealed that the PDW value was significantly higher and the platelet count was lower in the recovered patients than the unrecovered patients |
| Horibe et al. (2017) [29] |
Retrospective | 61 patients | 16–50 years | MPV, RDW | RDW can predict recovery from BP in patients aged 50 years and less |
| Wasano et al. (2017) [7] | Retrospective | 468 patients (BP 374, RHS 94) |
BP Mean 51.7 ± 14.18.8 (recovered), 57.6 ± 16.6 (unrecovered) RHS Mean 50.8 ± 18.7 (recovered), 50.5 ± 18.0 (unrecovered) |
Platelet, MCV | Palsy Prognosis Prediction scores (PPP score) are useful for predicting prognosis of facial palsy before beginning treatment |
| Sahin et al. (2017) [30] | Retrospective | 28 patients, 28 controls |
29.5 ± 10.5 (Mean) | MPV, RDW | Significant changes were not observed in NLR, PLR, MPV and RDW measurements in BP group between HBS |
| Zhao et al. (2016) [43] | Retrospective | 105 patients, 22 controls |
Fibrinogen | The plasma fibrinogen concentration was significantly higher in the group of patients with BP (HBS IV-VI) than the in the control group. The plasma fibrinogen levels became higher with the HBS grading increase | |
| Wasano et al. (2016) [32] | Retrospective | 468 patients (BP 374, RHS 94) |
Mean BP 51.7 ± 14.18.8 (recovered), 57.6 ± 16.6 (unrecovered) Mean RHS 50.8 ± 18.7 (recovered), 50.5 ± 18.0 (unrecovered) |
Platelet, Hbg, MCV | In the BP group, neutrophil rate, lymphocyte rate, NLR of recovered patients were significantly different than those of unrecovered patients. In RHS group monocyte rate, platelet count, MCV of recovered patients were significantly different than those of unrecovered patients |
| Özler, et al. (2014) [14] | Prospective | 30 patients, 30 controls |
39.9 ± 10.68, 37.1 ± 6.91 (Mean) | MPV, PDW, platelet | There was positive correlation between MPV values and grade of facial paralysis. Also, there was positive correlation between PDW values and grade of facial paralysis. In contrast, there was no correlation between MPV and PDW values and prognosis of facial paralysis |
| Kum et al. (2014) [36] | Retrospective | 65 patients, 35 controls |
45 ± 3.2, 45.4 ± 4.1 (Mean) |
MPV | There was a positive and significant correlation between NLR and HBS of the patients. MPV did not show any significant correlation with any of the parameters studied |