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. 2021 Dec 30;23(1):387. doi: 10.3390/ijms23010387

Figure 2.

Figure 2

Selection of key receptors, ligands, signalling molecules, and transcriptional regulators of B lineage cells in AAV. B cells present many different receptors on their surface, each triggering specific signalling pathways that eventually lead to transcription of genes necessary for B cell specific and essential functions. Blue: ligands; brown: receptors; cream: effector molecules/signalling pathways. The circle represents the endosome, and the yellow semicircle the nucleus. Abbreviations: BAFF (B cell activating factor), APRIL (a proliferation-inducing ligand), BAFF-R (B cell activating factor receptor), BCMA (B cell maturation antigen), TACI (transmembrane activator and cyclophilin ligand interactor), BCR (B cell receptor), TLR (toll-like receptor), BTK (Bruton’s tyrosine kinase), SYK (spleen tyrosine kinase), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), JAK (Janus family tyrosine kinases), STAT (signal transducer and activator of transcription), PI3K (phpsphatidylinositol-3-kinase), LYN (Lck/Yes related novel protein tyrosine kinase).