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Schematic diagram of the mitochondrial delivery of RES. RES is encapsulated in cationic and mitochondria-fusogenic liposomes. Multiple β-MENDs are taken up by cardiomyocytes, and some escape into the cytoplasm where the positively charged β-MEND binds to negatively charged mitochondria via electrostatic interactions. The delivery of RES to the myocardial mitochondria results in an enhanced mitochondrial respiratory capacity.
