Skip to main content
. 2022 Jan 5;23(1):570. doi: 10.3390/ijms23010570

Figure 1.

Figure 1

Effects of BDNF on IL-1β, IL-6, and TNF-α secretion and mRNA expression. U937 cells, differentiated macrophages, and LPS-stimulated macrophages were cultured with different concentrations of BDNF (0, 1, 5, 20, 50, and 200 ng/mL) for 48 h (for cytokine secretion) or 4 h (for mRNA expression). The effects of different concentrations of BDNF for the secretion of (A) IL-1β, (B) IL-6, and (C) TNF-α in U937 cells, differentiated macrophages, and LPS-stimulated macrophages. The effects of different concentrations of BDNF for the mRNA expression of (D) IL-1β, (E) IL-6, and (F) TNF-α in U937 cells, differentiated macrophages, and LPS-stimulated macrophages (* p < 0.05; ** p < 0.01; *** p < 0.001).