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Effects of BDNF at concentrations of 1 ng/mL and 5 ng/mL in mitogen-activated protein kinase (MAPK) and c-Jun phosphorylation of U937 cells. The phosphorylation ratio of (A) extracellular signal-regulated kinases (ERK), (B) p38, (C) c-Jun N-terminal kinases (JNK) and (D) c-Jun in U937 cells after cultured with medium only, low concentration of BDNF (20 ng/mL) or high concentration of BDNF (200 ng/mL) for 48 h. (E) A representative case (** p < 0.01; *** p < 0.001).
