Figure 5.

The “circadian entrainment” and “circadian rhythm” KEGG pathway members encoded by genes differentially expressed in the wall of IJV (CAMK2G, GRIN2A, GRIN2B, PER3, NR1D1). In the KEGG graph, the proteins encoded by these genes are marked as colored circles: the red circle indicates the glutamate ionotropic receptor NMDA that contains subunit 2A and 2B coded by GRIN2A, GRIN2B; the pink circle indicates the CaMKIIγ protein kinase coded by CAMK2G; the blue circle indicates the PER proteins among which the period circadian clock 3 is coded by PER3; the light blue circle indicates the Rev-Erbα protein coded by NR1D1. In accordance with KEGG color codes, pink rectangles indicate disease genes; light blue rectangles indicate drug target; pink/light blue rectangles indicate disease gene and drug target elements; green rectangles indicate specific signaling pathway elements.