Table 1.
MS-GWAS genes differentially expressed between MS and control IJV walls.
| Gene Symbol | Gene Name | Regulation | MS-IJV | C-IJV | FC | p * |
|---|---|---|---|---|---|---|
| AFF1 | AF4/FMR2 family member 1 | up | 9.95 ± 0.30 | 8.84 ± 0.29 | 2.17 | 0.005 |
| ALDH1L1 | Aldehyde dehydrogenase 1 family member L1 | down | 6.03 ± 0.22 | 7.23 ± 0.36 | 2.29 | 0.004 |
| ARL11 | ADP ribosylation factor-like GTPase 11 | up | 3.11 ± 0.42 | 2.07 ± 0.32 | 2.06 | 0.010 |
| BATF | Basic leucine zipper ATF-like transcription factor | up | 10.52 ± 1.39 | 8.94 ± 0.46 | 2.99 | 0.049 |
| CAMK2G | Calcium/calmodulin dependent protein kinase II gamma | down | 6.80 ± 0.57 | 8.01 ± 0.48 | 2.31 | 0.019 |
| CD86 | CD86 molecule | up | 14.38 ± 0.89 | 11.30 ± 0.38 | 8.48 | 0.002 |
| DOCK10 | Dedicator of cytokinesis 10 | down | 8.71 ± 0.98 | 10.01 ± 0.44 | 2.47 | 0.038 |
| IL20RA | Interleukin 20 receptor subunit alpha | up | 7.57 ± 1.23 | 5.97 ± 0.39 | 3.00 | 0.034 |
| KCNIP1 | Potassium voltage-gated channel interacting protein 1 | up | 3.84 ± 0.66 | 2.65 ± 0.70 | 2.28 | 0.042 |
| LEF1 | Lymphoid enhancer binding factor 1 | up | 7.64 ± 0.44 | 6.29 ± 0.96 | 2.55 | 0.042 |
| LINC01108 | ncRNA | down | 2.09 ± 0.54 | 3.17 ± 0.60 | 2.12 | 0.034 |
| LOC100130476 | ncRNA | up | 3.33 ± 0.15 | 2.16 ± 0.35 | 2.24 | 0.047 |
| NR1D1 | Nuclear receptor subfamily 1 group D member 1 | up | 8.31 ± 0.97 | 6.45 ± 1.16 | 3.63 | 0.042 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, A4 | up | 14.07 ± 0.86 | 12.12 ± 0.33 | 3.86 | 0.007 |
| TEF | Thyrotroph embryonic factor | up | 9.02 ± 0.47 | 7.76 ± 0.91 | 2.40 | 0.045 |
| TMEM130 | Transmembrane protein 130 | down | 6.73 ± 0.31 | 7.94 ± 0.60 | 2.32 | 0.016 |
| TMEM47 | Transmembrane protein 47 | down | 9.60 ± 0.82 | 10.70 ± 0.54 | 2.21 | 0.043 |
| TTC28 | Tetratricopeptide repeat domain 28 | up | 8.72 ± 0.54 | 7.52 ± 0.33 | 2.30 | 0.011 |
MS-IJV and C-IJV columns, mean ± SD of the log-transformed (log2) expression values. The fold change (FC) is presented as an absolute value. * by moderate t-test, followed by the application of Benjamini–Hochberg multiple testing correction.