Table 1.
Corresponding amino acid substitutions among NDM-1 and its variants and its first source of spread.
| NDM-1 Variant | Location of Amino Acid(s) Substitution | Source Organism(s) | ||
|---|---|---|---|---|
| A-Helices | β-Strands | Loop | ||
| NDM-2 | - | - | P28A | A. baumannii |
| NDM-3 | D95N | - | - | E. coli |
| NDM-4 | - | - | M154L | E. coli |
| NDM-5 | - | V88L | M154L | E. coli |
| NDM-6 | A233V | - | - | E. coli |
| NDM-7 | D130N | - | M154L | E. coli |
| NDM-8 | D130G | - | M154L | E. coli |
| NDM-9 | - | - | E152K | K. pneumoniae |
| NDM-10 | - | A74T | R32S, G36D, G69S, G200R | K. pneumoniae |
| NDM-11 | - | - | M154V | E. coli |
| NDM-12 | G222D | - | M154L | E. coli |
| NDM-13 | D95N | - | M154L | E. coli |
| NDM-14 | D130G | - | - | A. lwoffii |
| NDM-15 | A233V | - | M154L | E. coli |
| NDM-16 | A233V | V88L | M154L | E. coli |
| NDM-17 | - | V88L | M154L, E170K | E. coli |
| NDM-18 | - | - | QRFGD (44-48) | P. rettgeri |
| NDM-19 | D130N | - | M154L, A233V | E. coli |
| NDM-20 | - | V88L | M154L, R270H | E. coli |
| NDM-21 | - | V88L | G69S, M154L | E. coli |
| NDM-22 | - | - | M248L | E. cloacae |
| NDM-23 | I101L | - | - | K. pneumoniae |
| NDM-24 | - | V88L | - | P. stuartii |
| NDM-25 | - | A55S | - | K. pneumoniae |
| NDM-26 | G222S | V88L | M154L | E. coli |
| NDM-27 | D95N, A233V | - | - | E. coli |
| NDM-28 | A266V | - | - | K. pneumoniae |
| NDM-29 | D130N | - | - | K. pneumoniae |
| NDM-30 | D223Y | - | - | K. oxytoca |
| NDM-31 | P171T | - | - | C. werkmanii |