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. 2021 Dec 31;23(1):426. doi: 10.3390/ijms23010426

Figure 2.

Figure 2

Dysbiosis and therapeutic intervention in chronic liver disease. The defective intestinal barrier due to the malfunction of the tight junctions promotes the translocation of bacterial products into the portal vein. Therapeutic interventions targeting gut microbiota composition or their metabolites have been attempted. TJ, tight junction; IL-22, interleukin-22; LPS, lipopolysaccharide; SCFAs, short-chain fatty acids; BAs, bile acids; FXR, farnesoid X receptor; FGF19, fibroblast growth factor 19.