Table 5.
SVM-based classification of prospectively collected amyloid-containing samples. The validation set consisted of 103 Congo positive cases with confirmed diagnosis by IEM. In total, 69 ATTR cases, 21 AL-L cases and 4 AL-K was included in the validation set. For the 4-protein model, four ATTR-cases were misclassified as AL-L, whereas for the 7-protein model one ATTR sample was misclassified as AL-K.
| Subtype Classification |
Amyloidogenic Proteins | Correct/Total | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|
| AA | Serum amyloid A-1 protein (SA) | 6/6 | 1.00 | 1.00 | 1.00 | 1.00 | 0.96 */0.99 |
| SA and Serum amyloid A-2 protein | 6/6 | 1.00 | 1.00 | 1.00 | 1.00 | ||
| AL-K | Immunoglobulin kappa light chain (IgK) | 4/4 | 1.00 | 1.00 | 1.00 | 1.00 | |
| IgK and Ig kappa constant | 4/4 | 1.00 | 0.99 | 0.80 | 1.00 | ||
| AL-L | Ig lambda-1 light chain (IgL-1) | 25/25 | 1.00 | 0.95 | 0.86 | 1.00 | |
| IgL-1 and Ig lambda constant 2 | 25/25 | 1.00 | 1.00 | 1.00 | 1.00 | ||
| ATTR | Transthyretin (four-protein model) | 64/68 | 0.94 | 1.00 | 1.00 | 0.90 | |
| Transthyretin (seven-protein model) | 67/68 | 0.99 | 1.00 | 1.00 | 0.97 |
* Accuracy for the four protein model.