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Populations (in percentages) of different opening states in the relaxed structures of KirBac W46R obtained through MDeNM simulations and single-channel recording of the mutant and KirBac3.1WT.
| Channel States | Kirbac3.1 WT (%) (16) | KirBac3.1 W46R (%) |
|---|---|---|
| Fully open | 6.8 | 7.4 |
| Fully closed | 50.2 | 49.3 |
| Half open 1 (124 open, 132 closed) | 28.8 | 32.5 |
| Half open 2 (132 open, 124 closed) | 14.2 | 10.8 |
| Current recordings of KirBac3.1 in planar lipid bilayers | 9.9 (±1.3, n = 1803) | 7.1 |
