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. 2022 Jan 5;23(1):577. doi: 10.3390/ijms23010577

Figure 3.

Figure 3

A gain of HSP60 reduces mt-dsRNA in the context of chronic HFD for 26 weeks. Paraformaldehyde-fixed paraffin-embedded liver tissue was used to determine the mt-dsRNA using immunofluorescence staining. (A) Representative stain image of each group. Brown color indicates positive signal of mt-dsRNA. (B) Positive signal percentage quantified using ImageJ. Data collected from six fields of view of each specimen and five to six specimens for each group are expressed as the mean ± SE. * p < 0.05 and ** p < 0.01 between the indicated groups. WT, wild-type mice; HFD, high-fat diet; HSP60Tg, mice harboring overexpression of heat shock protein 60; CD, chow diet; mt-dsRNA, mitochondria double-strain RNA.