Table 2.
Infection-related characteristics and clinical outcomes.
| Endocarditis Characteristics | Overall (n = 59) | Treatment | p | ||
|---|---|---|---|---|---|
| AC12 (n = 32) | AC24 (n = 17) | ACjoined (n = 10) | |||
| Type of endocarditis | 0.515 | ||||
| Left-side IE | 53 (89.8) | 29 (90.6) | 16 (94.1) | 8 (80.0) | |
| Right-side IE | 2 (3.4) | 1 (3.1) | 0 (0.0) | 1 (10.0) | |
| Left and right-side IE | 1 (1.7) | 1 (3.1) | 0 (0.0) | 0 (0.0) | |
| Other or unknown | 3 (5.1) | 1 (3.1) | 1 (5.9) | 1 (10.0) | |
| Native valve IE | 39 (66.1) | 25 (78.1) | 11 (64.7) | 3 (30.0) | 0.019 |
| Early prosthetic valve IE (<1 year) | 7 (11.9) | 2 (6.3) | 1 (5.9) | 4 (40.0) | 0.010 |
| Late prosthetic valve IE (>1 year) | 10 (16.9) | 5 (15.6) | 3 (17.6) | 2 (20.0) | 0.946 |
| Cardiac device-related IE | 3 (5.1) | 0 (0.0) | 2 (11.8) | 1 (10.0) | 0.151 |
| Valve involvement | |||||
| Aortic valve | 28 (47.5) | 16 (50.0) | 8 (47.1) | 4 (40.0) | 0.858 |
| Mitral valve | 14 (23.7) | 8 (25.0) | 4 (23.5) | 2 (20.0) | 0.948 |
| Mitral and aortic valves | 11 (18.6) | 5 (15.6) | 4 (23.5) | 2 (20.0) | 0.790 |
| Mitral and tricuspid valves | 1 (1.7) | 1 (3.1) | 0 (0.0) | 0 (0.0) | 0.651 |
| IVC and tricuspid valve | 2 (3.4) | 1 (3.1) | 0 (0.0) | 1 (10.0) | 0.380 |
| Other or unknown | 3 (5.1) | 1 (3.1) | 1 (5.9) | 1 (10.0) | 0.678 |
| Cardiac Surgery | |||||
| Cardiac surgery indicated * | 32 (54.2) | 20 (62.5) | 10 (58.8) | 2 (20.0) | 0.049 |
| Cardiac surgery performed (% of indicated) | 24 (75.0) | 18 (90.0) | 6 (60.0) | 0 (0.0) | 0.008 |
| Clinical outcomes | |||||
| Relapses | 6 (10.2) | 0 (0.0) | 5 (29.4) | 1 (10.0) | 0.005 |
| Side effects related to AC | 7 (11.9) | 6 (18.8) | 0 (0.0) | 1 (10.0) | 0.152 |
| Unplanned readmission | 17 (28.8) | 9 (28.1) | 6 (35.3) | 2 (20.0) | 0.693 |
| Readmission unrelated to IE | 8 (13.6) | 5 (15.6) | 2 (11.8) | 2 (20.0) | 0.260 |
| Readmission related to IE | 9 (15.3) | 4 (12.5) | 5 (29.4) | 0 (0.0) | |
| Final outcome | |||||
| Cured | 54 (91.5) | 30 (93.8) | 16 (94.1) | 8 (80.0) | 0.177 |
| Death unrelated to IE | 2 (3.4) | 1 (3.1) | 1 (5.9) | 0 (0.0) | |
| Death related to IE | 3 (5.1) | 1 (3.1) | 0 (0.0) | 2 (20.0) | |
Bold indicates statistical significance, IQR = Interquartile range, IE = Infective endocarditis, AC = Ampicillin plus ceftriaxone treatment, IVC = Interventricular communication, * Surgical indications were evaluated according to the American Association for Thoracic Surgery (AATS) guidelines [18].