Table 2.
Reactome pathways. Table shows pathways in which proteins identified as chaperones in STRING diagram are involved (p value < 0.05).
| Identifier | Pathway Name | #Found | #Total | p Value | FDR | Submitted Entities Found |
|---|---|---|---|---|---|---|
| R-HSA-422475 | Axon guidance | 21 | 558 | 1.80 × 10−5 | 0.0056 | AP2A2, HSP90AA1, DAG1, CLASP2, MAP2K1, DPYSL5, AP2A1, EZR, PRKACA, RPL35, CSNK2A1, PLXNA4, DPYSL4, DLG3, DLG4, CRMP1, MSN, RPS25, HSP90AB1, PFN2, RPLP2 |
| R-HSA-69275 | G2/M Transition | 11 | 198 | 7.85 × 10−5 | 0.0065 | PRKACA, DCTN1, HSP90AA1, PPP2R2A, CKAP5, PPME1, SKP1, PAFAH1B1, PPP2R1A, HSP90AB1, PRKAR2B |
| R-HSA-3371568 | Attenuation phase | 3 | 14 | 9.22 × 10−4 | 0.0350 | HSP90AA1, HSP90AB1, FKBP4 |
| R-HSA-399954 | Sema3A PAK dependent Axon repulsion | 3 | 16 | 0.00135 | 0.0459 | HSP90AA1, PLXNA4, HSP90AB1 |
| R-HSA-9613829 | Chaperone Mediated Autophagy | 3 | 22 | 0.00331 | 0.0744 | HSP90AA1, HSP90AB1, GFAP |
| R-HSA-168249 | Innate Immune System | 27 | 1187 | 0.00399 | 0.0744 | HMGB1, HSP90AA1, S100A1, PPIA, PRDX6, FABP5, C4B, C4B_2, SUGT1, BAIAP2, SKP1, HEBP2, GSTP1, GPI, AP2A2, PIN1, COTL1, HSP90B1, MGST1, PPP2R1A, MAP2K1, PADI2, MAPK10, UBE2M, PRKACA, HMOX2, CD44, HSP90AB1 |
| R-HSA-5336415 | Uptake and function of diphtheria toxin | 2 | 7 | 0.00405 | 0.0744 | HSP90AA1, HSP90AB1 |
| R-HSA-5339562 | Uptake and actions of bacterial toxins | 4 | 48 | 0.00407 | 0.0744 | HSP90AA1, PDCD6IP, MAP2K1, HSP90AB1 |
| R-HSA-3371571 | HSF1-dependent transactivation | 3 | 24 | 0.00421 | 0.0744 | P07900, P08238, Q02790 |
| R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) | 4 | 57 | 0.00921 | 0.0760 | DCTN1, HSP90AA1, HSP90AB1, FKBP4 |
| R-HSA-3371556 | Cellular response to heat stress | 5 | 95 | 0.01141 | 0.0799 | HSP90AA1, HSPA4L, BAG3, HSP90AB1, FKBP4 |
| R-HSA-3371511 | HSF1 activation | 2 | 12 | 0.04212 | 0.1685 | HSP90AA1, HSP90AB1 |
| R-HSA-449147 | Signaling by Interleukins | 11 | 456 | 0.04615 | 0.1728 | HMGB1, PRKACA, HSP90AA1, PPIA, FSCN1, HSP90B1, SKP1, PPP2R1A, MAP2K1, MSN, MAPK10 |
| R-HSA-8953897 | Cellular responses to external stimuli | 13 | 579 | 1.80 × 10−5 | 0.0056 | CSRP1, DCTN1, HSP90AA1, HSPA4L, PRDX6, MAPK10, FKBP4, RPL35, BAG3, GSTP1, RPS25, HSP90AB1, RPLP2 |