Table 5.
Analysis of the attrition rate of various filters for the protease-inhibitor-targeted library.
| ApexBio | Asinex | Chemdiv | Enamine | LifeChemicals | Otava | SelleckChem | TargetMol | |
|---|---|---|---|---|---|---|---|---|
| Unfiltered | 824 | 6640 | 41,801 | 117 | 25,535 | 8034 | 227 | 295 |
| Isolated filter: | Number of filtered out compounds (%) | |||||||
| REOS | 397(48%) | 273(4%) | 2151(5%) | 54(46%) | 3583(14%) | 1025(13%) | 110(48%) | 146(49%) |
| PAINS | 58(7%) | 129(2%) | 1060(3%) | 7(6%) | 430(2%) | 307(4%) | 7(3%) | 16(5%) |
| Aggregators | 294(36%) | 3254(49%) | 29,313(70%) | 36(31%) | 14,059(55%) | 4216(52%) | 88(39%) | 118(40%) |
| Lipinski Ro5 | 113(14%) | 0(0%) | 1045(2%) | 11(9%) | 409(2%) | 2(~0%) | 37(16%) | 55(19%) |
| All filters | 743(90%) | 5019(76%) | 37,137(89%) | 106(91%) | 23,215(91%) | 6987(87%) | 208(92%) | 272(92%) |