Table 1.
Histopathological analysis of various tissues or organs in hACE2 transgenic mice immunized with the heterologous vaccine administered intradermally after B.1.617.2 strain challenge.
| Organ | Group | Day post infection | ||
|---|---|---|---|---|
| 3 | 7 | 11 | ||
| Brain | MB-1 | − | / | / |
| MB-2 | − | / | / | |
| MA-1 | − | −∼+ | −∼+ | |
| MA-2 | − | −∼± | − | |
| MA-3 | − | − | −∼+ | |
| MA-4 | − | − | − | |
| Heart | MB-1 | − | / | / |
| MB-2 | −∼++ | / | / | |
| MA-1 | − | − | − | |
| MA-2 | −∼± | − | − | |
| MA-3 | − | − | − | |
| MA-4 | − | − | − | |
| Liver | MB-1 | + | / | / |
| MB-2 | + | / | / | |
| MA-1 | −∼± | −∼± | −∼± | |
| MA-2 | ±∼+ | ±∼+ | ±∼+ | |
| MA-3 | −∼+ | −∼± | ±∼+ | |
| MA-4 | −∼± | −∼+ | −∼± | |
| Spleen | MB-1 | − | / | / |
| MB-2 | − | / | / | |
| MA-1 | − | − | − | |
| MA-2 | − | − | − | |
| MA-3 | − | − | − | |
| MA-4 | − | − | − | |
| Kidney | MB-1 | − | / | / |
| MB-2 | − | / | / | |
| MA-1 | − | − | − | |
| MA-2 | − | − | − | |
| MA-3 | −∼± | − | − | |
| MA-4 | − | − | − | |
| Gnitals | MB-1 | − | / | / |
| MB-2 | − | / | / | |
| MA-1 | − | − | − | |
| MA-2 | − | − | − | |
| MA-3 | − | − | − | |
| MA-4 | − | − | − | |
Note: −, no significant pathological changes; ±, very light pathological changes; +, light pathological changes; ++, mild pathological changes; +++, severe pathological changes