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. 2021 Dec 31;23(1):450. doi: 10.3390/ijms23010450

Figure 4.

Figure 4

Interfering β-catenin sensitizes HT1197 cells to paclitaxel. (A) Western blots of PARP, cleaved caspase-3, total β-catenin, and active β-catenin in HT1197 cells transfected with siRNA β-catenin or non-targeting siRNA and treated with DMSO (vehicle) or 0.1 µM paclitaxel for 48 h, and (B) Western blots of PARP, cleaved caspase-3, total β-catenin, active β-catenin, p-GSK3βSer9, ALDH1A1, Sox-2 and Oct-4 in HT1197 cells treated with DMSO (vehicle), 10 µM XAV939, 0.1 µM paclitaxel or 0.1 µM paclitaxel plus 10 µM XAV939 for 48 h. β-actin was used as a loading control. Histograms show the densitometric analysis of the indicated proteins. Data are presented as mean ± SD. * p value < 0.05 from Student’s t test (n ≥ 3). ns, not significant.