Table 1.
Clinical Trials that utilized MSCs in ischemic heart diseases.
| Study | Clinical Trials Identifier: | Intervention | Delivery Method | Disease | Phase | Status | Reference |
|---|---|---|---|---|---|---|---|
| A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human MSC (prochymal) after acute myocardial infarction | NCT00114452 | Allogeneic hMSCs | IV | myocardial infarction | Phase I | Completed | [59] |
| Safety Study of Adult Mesenchymal Stem Cells (MSC) to Treat Acute Myocardial Infarction | NCT00114452 | Provacel ex vivo cultured adult MSCs |
IV | Myocardial Infarction | Phase I | Completed | [59] |
| Intramyocardial Injection of Autologous Bone Marrow-Derived Ex Vivo Expanded Mesenchymal Stem Cells in Acute MI Patients is Feasible and Safe up to 5 Years of Follow-up | Dutch trial registry (NTR1553) | Autologous BM-MSCs | Intramyocardial injection | Acute ST-segment elevation MI | Completed | [60] | |
| Intracoronary cardiosphere-derived cells for heart regeneration after MI (CADUCEUS): a prospective, randomized phase I trial | NCT00893360 | Autologous stem cell infusion | Intracoronary infusion | Recent Myocardial Infarction Ventricular Dysfunction |
Phase I | Completed | [64] |
| Comparison of allogeneic vs. autologous BM-MSC delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial | NCT01087996 | Auto-hMSCs Allo-hMSCs |
Transendocardial Injection | LV dysfunction due to ICM | Phase I Phase II |
Completed | [65] |
| Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS) | NCT00587990 | MSC injection | Intramyocardial injection | Left Ventricular Dysfunction | Phase I Phase II |
Terminated (Difficulty in recruitment.) | [66] |
| Adipose-derived regenerative cells in patients with ischemic cardiomyopathy: The PRECISE Trial | NCT00426868 | Direct injection of (ADRCs) | Direct injection into the Left Ventricle | coronary artery disease refractory to revascularization | Phase I | Completed | [67] |
| Rationale and design of the first randomized, double-blind, placebo-controlled trial of intramyocardial injection of autologous BM-MSCs in chronic ischemic Heart Failure (MSC-HF Trial) | NCT00644410 | Autologous BM-MSC | Intramyocardial injection | Congestive Heart Failure | Phase I Phase II |
Completed | [68] |
| Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) | NCT00810238 | BM- cardiopoietic cells | LV endocardial injection | heart failure Class II or III of ischemic origin | Phase II Phase III |
Completed | [69] |
| Prochymal® (Human Adult Stem Cells) Intravenous Infusion Following Acute Myocardial Infarction (AMI) | NCT00877903 | Prochymal® (Human Adult Stem Cells) | IV infusion | Myocardial Infarction | Phase II | Completed | - |
| Safety Study of Allogeneic Mesenchymal Precursor Cell Infusion in MyoCardial Infarction (AMICI) | NCT01781390 | Mesenchymal Precursor Cells (MPC) | Intracoronary infusion | Acute Myocardial Infarction | Phase II | Active, not recruiting | - |