Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
While YAP does not drive long-term mechanical memory in vitro, cell memory may potentially be regulated by nuclear reprogramming (e.g., altered epigenetics and/or microRNA expression) (41, 59). Increased pro-regenerative cytokine secretion (e.g., MCP-1, IGFBP-6, Endocan) after soft priming may signal to the resident cell population in vivo to mitigate the fibrotic wound healing response in our rat elbow contracture model which subsequently improved joint motion.
