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. 2022 Jan 4;23(1):534. doi: 10.3390/ijms23010534

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Treatment with kMSC improves GvHD clinical score and survival. Acute GvHD progression was studied in a model of lethal GvHD of haploidentical hematopoietic cell transplants induced by infusion of parental splenocytes into F1 chimeras. (a) Representative flow cytometric analysis of the engrafted cells (B6SJL, CD45.1⁺) in the recipient mice (F1, CD45.2⁺) at 3 weeks after transplant. (b) Quantification of engraftment in the transplanted mice. Each dot represents one mouse (n = 9 for BM, n = 10 for BM + SP, n = 10 for BM + SP + evMSC, and n = 9 for BM + SP + kMSC). (c) Survival curves for the experimental groups. (d) Graphical representation of the clinical score values 18 days after transplantation. (e) Evolution of the clinical score after transplantation. Each line represents one mouse. Error bars are means ± SD, *** p < 0.001, and **** p < 0.0001.