Table 1.
Oncological and Reproductive outcomes of fertility-sparing treatment of endometrial cancer.
| First Author and Year | N. of Patient | Histology | Type of Treatment | Complete Response Rate | Recurrence Rate | Pregnancy Rate | Live Birth Rate |
|---|---|---|---|---|---|---|---|
| Ramirez 2004 | 81 | EEC | OP | 76% | 24% | N.A. | N.A. |
| Gallos 2012 | 559 | 408 EEC 151 AEH |
N.A. | 76.2% 85.6% |
40.6% 26% |
N.A. N.A. |
28% 26.3% |
| Falcone 2017 | 28 | EEC | HR + OP/HR + LNG-IUS | 96.3% | 7.7% | 93.3% 1 | 86.6% 1 |
| Fan 2017 | 619 | EEC | HR + OP OP LNG-IUS |
95.3% 76.3% 72.9% |
14.1% 30.7% 11% |
47.8% 52.1% 56% |
N.A N.A. N.A. |
| Wei 2017 | 1038 | EEC/AEH | OP LNG-IUS OP + LNG-IUS |
71% 76% 87% |
20% 9% N.A. |
34% 18% 40% |
20% 14% 35% |
| Giampaolino 2018 | 69 | 14 EEC 55 AEH |
HR + LNG-IUS | 78.6% 92.7% |
18.2% 3.9% |
0% 26.3% 1 |
0% 26.3% 1 |
EEC, Early Endometrial Cancer; AEH, Atypical Endometrial Hyperplasia; OP, Oral Progestins; HR, Hysteroscopic Resection; LNG-IUS, Levonorgestrel Intrauterine System. 1 Considering only women who tried to conceive.