Figure 2.

The effects of early or late treatment with Necrosatin-1 (Nec-1), an RIPK1 inhibitor, on mechanical allodynia in rats with an inferior alveolar nerve injury. (A–C) The intracisternal administration of Nec-1 (1 or 10 μg) produced anti-allodynic effects compared to the vehicle. The treatment with Nec-1 significantly attenuated mechanical allodynia on POD 3, 7, and 21 (repeated measure ANOVA with Holm–Sidak post hoc tests, n = 7). All mean ± SEM, * p < 0.05, vehicle vs. Nec-1-treated group.