Skip to main content
. 2021 Dec 29;23(1):348. doi: 10.3390/ijms23010348
ATM ataxia telangiectasia mutated
ATR ATM- and Rad3-related
BACH1 BRCA1-associated C-terminal helicase 1
BARD1 BRCA1 Associated RING domain 1
BRIP1 BRCA1 interacting helicase 1
CAP College of American Pathologist
CHEK2 checkpoint kinase 2
CHK2 CHEK2 gene coding checkpoint kinase 2 protein
CLIA Clinical Laboratory Improvement Amendments
CtIP CtBP-interacting protein
DSB double strand break
GPV germline pathogenic variant
HBOC hereditary breast and ovarian cancer syndrome
HER2 human epidermal growth factor
HGSC high-grade serous carcinoma
HR homologous recombination
HRD homologous recombination deficiency
MGPT multi-gene panel testing
NGS next-generation sequencing
MMEJ microhomology-mediated end-joining
NHEJ non-homologous end-joining
MRN MRE11-RAD50-NBS1 (or NBN)
NES nuclear exporting signal
PALB2 partner and localizer of BRCA2
PARP poly (ADP-ribose) polymerase
PARPi poly (ADP-ribose) polymerase inhibitors
RPA replication protein A
RRSO risk-reducing salpingo-oophorectomy
TNBC triple-negative breast cancer
VUS variant of unknown significance