Figure 7.

Schematic representation of the immune response of CD3⁺TCRαβ⁺ and CD3⁺TCRαβ⁻ myocyte-derived macrophage (MDM) subpopulations to Mycobacterium tuberculosis (Mtb) infection. Human monocytes that are differentiated into macrophages and then infected with the H37Ra or H37Rv Mtb strains display a different phenotype and cytokine microenvironments in response to the infection. CD3⁺TCRαβ⁺ and CD3⁺TCRαβ⁻ MDM subpopulations show differential expression of molecules of the TNF/TNFRs axis, antigen-presenting molecules of MHC class II, and the CD1 family (of protein and lipid, respectively), and chemokine receptors depending on Mtb virulence. The immunological profile generated by H37Rv infection affects the migration ability of MDMs, but interestingly, the migration ability of CD3⁻ MDMs is decreased, whereas that of CD3⁺ MDMs remains intact. The changes are indicated when both MOIs modified the phenotype to simplify the summary of the characterization.