Baldi 1991.

Methods	RCT
Participants	71 patients with IBS 8 GI centres Mean age 40 years 60.6% female
Interventions	Spasmolytic 4 weeks otilonium 40 mg tds
Outcomes	abdominal pain
Notes	2 wk run‐in with placebo
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Double‐blind, methods not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	One drop‐out
Selective reporting (reporting bias)	Low risk	All expected outcomes were reported
Other bias	Low risk	The study appears to be free of other sources of bias