Drossman 2003.

Methods	RCT
Participants	216 patients with functional bowel disorders, 80% with IBS Secondary care Rome criteria Mean age 39.9 years 100% female
Interventions	Antidepressant desipramine 50‐100‐150mg od for 12 weeks
Outcomes	Abdominal pain, continuous and dichotomous Global assessment, continuous and dichotomous Symptom score, continuous and dichotomous
Notes	No run‐in; minimum duration of symptoms of 6 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated
Allocation concealment (selection bias)	Low risk	Adequate
Blinding of participants and personnel (performance bias) All outcomes	High risk	Investigator‐blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	Missing outcome data balanced in numbers across intervention groups with similar reasons for missing data across groups
Selective reporting (reporting bias)	Low risk	All expected outcomes were reported
Other bias	Low risk	The study appears to be free of other sources of bias