Fielding 1980.

Methods	RCT
Participants	60 IBS patients Unclear setting Diagnostic criteria not defined Mean age 26 years 75% female mean duration of symptoms 2 years
Interventions	Spasmolytic trimebutine tds 200 mg for 6 months
Outcomes	Abdominal pain, dichotomous Global assessment, dichotomous
Notes	No run‐in
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind, identical placebo
Incomplete outcome data (attrition bias) All outcomes	Low risk	7 drop‐outs
Selective reporting (reporting bias)	Low risk	All expected outcomes were reported
Other bias	Low risk	The study appears to be free of other sources of bias