Kruis 1986.

Methods	RCT
Participants	80 patients Outpatients clinic Mean age 41 years 61% female
Interventions	Bulking agent 16 weeks wheat bran fibre 8 g/day Spasmolitic agent 16 weeks mebeverine 100 mg 4 dd
Outcomes	Global assessment, dichotomous Abdomianl pain, dichotomous
Notes	GI patients No run‐in
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Mebeverine and placebo arms were double‐blind. Methods not described
Incomplete outcome data (attrition bias) All outcomes	Low risk	Missing outcome data balanced in numbers across intervention groups with similar reasons for missing data across groups
Selective reporting (reporting bias)	Low risk	Expected outcomes were reported
Other bias	Low risk	The study appears to be free of other sources of bias