Pulpeiro 2000.

Methods	RCT
Participants	85 IBS patients Hospital GI department Mean age 45.2 years 69% female
Interventions	Spasmolytic Propinox 4 dd for 4 weeks
Outcomes	Abdominal pain, continuous Global assessment, dichotomous
Notes	No run‐in Dose unclear
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Low risk	Adequate
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind, identical placebo
Incomplete outcome data (attrition bias) All outcomes	Low risk	No drop‐outs
Selective reporting (reporting bias)	Low risk	Expected outcomes reported
Other bias	Low risk	The study appears to be free of other sources of bias