Talley 2008a.
| Methods | RCT | |
| Participants | 51 patients Setting secondary care Rome criteria 60% female 70% diarrhea predominant |
|
| Interventions | Antidepressive Imipramine (TCA) 50 mg dd for 12 weeks Citalopram (SSRI) 40 mg dd for 12 weeks |
|
| Outcomes | Abdominal pain, changes score (not included) global assessment, dichotomous and change score (not included) |
|
| Notes | 2 weeks run‐in period | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Computer generated |
| Allocation concealment (selection bias) | Low risk | Centralized randomization by hospital pharmacy |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | Double‐blind, double‐dummy, identical capsules |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Reasons for drop‐out not provided |
| Selective reporting (reporting bias) | Low risk | Expected outcomes reported |
| Other bias | Low risk | The study appears to be free of other sources of bias |