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. 2011 Aug 10;2011(8):CD003460. doi: 10.1002/14651858.CD003460.pub3

Pace 2010.

Methods RCT
Participants 186 IBS patients (Rome II)
Interventions Antispasmodic
octatropine (40 mg BID) and diazepam (2.5 mg BID) or placebo
Outcomes Satisfactory relief of abdominal pain
abdominal swelling
abdominal pain and discomfort
symptom severity
number of bowel movements
Notes