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. 2021 Dec 23;23(1):141. doi: 10.3390/ijms23010141

Figure 8.

Figure 8

RvD1 uses β-ARK1 to counter-regulate increase in [Ca2+]i induced by H3 agonist. H3 agonist ((R)-(-)-α-methylhistamine, 10−5 M) was added alone (solid black line in a; first bar in b). RvD1 (10−8 M) was added followed by H3 agonist 30 min later (turquoise line in a; second bar in b). β-ARK1 inhibitor β-ARK1I (10−6 M) was given 30 min prior to addition of H3 agonist (dotted black line in a; third bar in b). β-ARK1 inhibitor β-ARK1I (10−6 M) was given 15 min prior to RvD2 (10−8 M) treatment followed 30 min later by H3 agonist (blue line in a; fourth bar in b). The average [Ca2+]i level over time was shown in (a); change in peak [Ca2+]i was calculated and shown in (b). Data are mean ± SEM from 5 rats. * Indicates a significant difference from basal. # Indicates a significant difference from stimulus alone. Arrow indicates addition of H3 receptor agonist.