Table 1.

Summary of protein kinases activated by RvD1 and RvD2 to counter-regulate H1–4 receptor subtypes.

		RvD2			RvD1
H Receptors	Pathway	β-ARK1	PKA	PKC	β-ARK1	PKA	PKC
H1	Gq-PKC-IP3	+	+	–	+	+	+
H2	Gαs—cAMP	Not inhibited by RvD2			Not inhibited by RvD1
H3	Gαi/o	–	+	–	+	+	+
H4	Gαi/o	+	–	+	Not inhibited by RvD1

H, histamine; RvD, resolvin D; PKC, protein kinase C; IP3, Inositol trisphosphate; β-ARK1, β adrenergic receptor kinase 1; PKA, protein kinase A; G, G protein coupled receptor.