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. 2021 Dec 24;23(1):195. doi: 10.3390/ijms23010195

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Alterations in the serum metabolome of iNOS^-/- mice following treatment with various interventions. Serum metabolomic analysis in chow fed WT, iNOS^-/- and iNOS^-/- mice treated with various interventions in ESI (+) mode (A) PLS-DA score plot. Heat map of differential metabolites identified by metabolomics analysis related to (B) Nucleic acids metabolism, (C) Carbohydrate metabolism and (D) Miscellaneous/microbiota derived metabolites. Data are represented as mean (n ≥ 4). * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. WT; # p < 0.05, ## p < 0.01, ### p < 0.001 and #### p < 0.0001 vs. iNOS^-/-.