Figure 1.

Regulation of the first committed step in LPS biosynthesis catalyzed by LpxC. On the top schematic drawing of the interaction between LapB and LapC in the inner membrane, and scissors depict LpxC proteolysis by FtsH and HslVU proteases. The LpxC synthesis is also subjected to negative post-transcriptional regulation by the GcvB sRNA. At the bottom, the recruitment of UDP-GlcNAc and (R)-3-hydroxymyristate precursors in LPS biosynthesis is shown. The same (R)-3-hydroxymyristate precursor is used by FabZ in phospholipid biosynthesis. UDP-GlcNAc synthesis requires GlmS, whose amounts are regulated by GlmY and GlmZ sRNAs, requiring RapZ as an adaptor protein.