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. 2021 Dec 29;23(1):382. doi: 10.3390/ijms23010382

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TF-miRNA-mRNA network. (A) Network analysis of 5 uniquely upregulated DE-miRNAs (red), 14 predicted targets (blue), and 12 predicted TFs (yellow) by Cytoscape. The size of the shape represents the degree of the nodes. Solid arrow, miRNA targets mRNA or TF activates miRNA; line dotted arrow, TF regulates miRNA; dotted arrow, TF regulates (feedback) miRNA. (B) Network analysis of 13 uniquely downregulated DE-miRNAs (red), 67 predicted targets (blue), and 11 predicted TFs (yellow) by Cytoscape. The size of the shape represents the degree of the nodes. Solid arrow, miRNA targets mRNA or TF activates miRNA; line dotted arrow, TF regulates miRNA; dotted arrow, TF regulates (feedback) miRNA; double solid, TF represses miRNA.