Table 1.

miR-539 and miR-582 target many genes in ECs and SMCs. Genes regulated by miR-539 and miR-582 in ECs and SMCs according to the data obtained by RNA sequencing. Data were compared with the lists of predicted target genes available on TargetScan and then analyzed with Gene Ontology to highlight the biological processes where identified target genes are involved.

GO ID	Biological Processes	Matched Genes in the Network	Genes in the Networks	False Discovery Rate
miR-539 in ECs
GO:0030336	negative regulation of cell migration	28	237	0.00093
GO:0008284	positive regulation of cell population proliferation	69	878	0.002
miR-582 in ECs
GO:0035295	tube development	59	793	1.37 × 105
GO:0008284	positive regulation of cell population proliferation	58	878	0.00035
GO:0001568	blood vessel development	44	464	1.49 × 106
GO:0001525	angiogenesis	30	297	4.72 × 105
miR-539 in SMCs
GO:0008285	negative regulation of cell population proliferation	18	669	0.0247
GO:0030334	regulation of cell migration	20	753	0.0194
GO:0045765	regulation of angiogenesis	14	277	0.0044
miR-582 in SMCs
GO:0008285	negative regulation of cell population proliferation	103	669	0.0016
GO:0030335	positive regulation of cell migration	81	452	0.00015
GO:1901342	regulation of vasculature development	58	305	0.00067