. 2021 Dec 27;23(1):259. doi: 10.3390/ijms23010259

Table 4.

Data from the 15 most potent covalent inhibitors of the SARS-CoV-2 M-pro.

Compound	IC₅₀ μM (pIC₅₀)	EC₅₀ μM	CC₅₀ μM	Reference
Z-AVLD-FMK	0.0009 (9.05)	66.0 ^a	-	[97]
2683066-42-2 (15h)	0.001 (9.0)	0.16 ^a	>200	[71]
2683066-41-1 (15g)	0.0064 (8.19)	0.52 ^a	>200	[71]
PF-00835231 (4)	0.0057–0.008 0.0072 ^b (8.14)	88.9 ^a	>100 ^a	[93,104,105,106]
MI-21	0.0076 (8.12)	2.97 ^a	>500 ^a	[59]
MI-23	0.0076 (8.12)	5.63 ^a	>500 ^a	[59]
MI-28	0.0092 (8.04)	0.67 ^a	>500 ^a	[59]
UAWJ248	0.012 (7.92)	20.49 ^a	>250 ^a	[70]
MI-13	0.0124 (7.91)	2.08	>500 ^a	[59]
MI-14	0.0130 (7.89)	0.66 ^a	>500 ^a	[59]
MI-05	0.0132 (7.88)	5.57 ^a	>500 ^a	[59]
MI-11	0.0133 (7.88)	1.18 ^a	>500 ^a	[59]
2683066-47-7 (15m)	0.014 (7.85)	0.47 ^a	>200	[71]
MI-06	0.0145 (7.84)	1.73 ^a	>500 ^a	[59]
MI-09	0.0152 (7.82)	0.86 ^a	>500 ^a	[59]

^a In Vero E6 cells. ^b Mean value of multiple IC₅₀.