Table 2.

Anti-cancer activities of protopine.

Cancer Type	Cell Line	Mechanism	References
Liver Cancer	HepG2		[23]
	HepG2 and Huh-7	es regulates ROS/PI3K/Akt signaling pathway and the intrinsic pathway	[21]
Colon Cancer	HCT116	induces apoptosis and autophagy by stabilizing p53	[26]
	SW480		[23]
Breast Cancer	MDA-MB-231	anti-adhesion and anti-invasive	[30]
Pancreatic Cancer	MIA Paca-2 and PANC-1		[33]
Prostate Cancer	HRPC	regulates Cdk1 activity and Bcl-2 family of proteins.	[35]
Lung Cancer	A549_		[23]