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Reagents: (a)(1) s-buLi, Et2O, TMDA, −40 °C, 3 h, (2) B(OCH3)3, (3) NaOH, (4) HCl; (b)(1) (+)pinanediol, Et2O, 2 h; (c) (1) Boc-D-alanine, CH2CL2, HOBT, EDC, 30 min, 0 °C, (2) 3a, NMM, 8 h, (3) TFA, (4)H2O, Na2CO3, KHSO4; (d) (1) 4a, H2O, (2) PhB(OH)2, hexane, 24 h; (e) (1) Succinimidyl-N-Boc-hynic, DIPEA, HATU, DMF, 15 min, (2) 5, 2 h, (3) TFA; and (f) (1) EDDA/tricine (2) 6, (3) 99mTcO4Na/SnCl2, 15 min, 92 °C; and 7, proposed structure of the final product.
