Table 1.

Summary of TQ application in clinical trials for various diseases.

Disease	Study Type	Major Clinical Findings	Ref.
Intractable pediatric seizures	Double-blinded crossover clinical trial	The frequency of seizures decreased significantly with extract of Nigella sativa	[276]
Advanced Refractory Malignant Disease	Open-label, non-randomized cohort study	TQ had no adverse effects and no anti-cancer effects	[277]
Polycystic Ovary Syndrome (PCOS)	Randomized clinical trial	Supplementing black cumin oil with metformin improves PCOS-related symptoms	[278]
Type II Diabetes millets	Randomized double-blind, placebo-controlled trial	Fasting blood sugar, glycated hemoglobin, triglyceride, and low-density lipoprotein–cholesterol levels all changed considerably in the intervention group (Nigella sativa) compared to the placebo group.	[279]
Ulcerative colitis	Prospective, randomized, double-blind, placebo-controlled trial	No significant difference between the two groups (Placebo vs. Nigella sativa)	[280]
Asthma disease	Double-blind, placebo-controlled trial	All asthma symptoms, frequency of asthma symptoms/week, chest wheezing, and pulmonary function tests values in the study group (Nigella sativa) had significantly improved	[281]