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. 2022 Jan 5;27(1):311. doi: 10.3390/molecules27010311

Figure 1.

Figure 1

Domain architecture of EPAC1 and EPAC2 isoforms. EPAC1 and EPAC2 isoforms consist of N-terminal cAMP-binding domains and C-terminal guanine nucleotide exchange factor (GEF) domain. The REPAC isoform lacks the cAMP binding (CNB) domain. The N-terminal regulatory region includes a disheveled Egl-10 pleckstrin homology domain and one or two cyclic nucleotide binding domains. The C-terminal catalytic region contains a RAS exchange motif, a RAS-association domain, and a CDC25 homology domain.