Figure 7. Genetic inhibition of SASP in p21^high cells in vivo.

(a) Schematic of floxed Rela mice. (b) Schematic of P-Rela and Rela mice. (c) PCR results using Rela-F, Rela-WT-R, Rela-Cut-R primers for SVF from P-Rela and Rela mice. Experiments were repeated in 3 mice. (d) Relative mRNA expression in senescent WT and CAG-Rela ear fibroblasts. n=6 for both groups. Results are shown as means ± s.e.m. * p< 0.05; two-tailed, unpaired Student’s t-test. p<0.001 for Rela; p=0.037 for Il6; p=0.033 for Cxcl1; p=0.005 for Ccl2.