Figure 8. Clearance of p21high cells improves physical function in old mice.
(a) Experimental design. (b) Bodyweight, (c) Maximal walking speed, and (d) Grip strength was measured in PL and PLD mice (both male and female) at age 20 months (before tamoxifen treatment) and 23 months (after tamoxifen treatment, p=). (e) Hanging endurance, (f) Food intake, and (g) Daily activity was measured at age 23 months. n=9 for both groups. Results are shown as means ± s.e.m. * p< 0.05; two-tailed, unpaired Student’s t-test. For c, p=0.026 for 23 months; p=0.001 for baseline%. For d, p<0.001 for 23 months; p=0.020 for baseline%. For e, p=0.044. For f, p=0.017, 0.006, 0.022, 0.004 for D1, N1, D2, N2 respectively. For g, p=0.001, 0.001, 0.026, 0.062 for D1, N1, D2, N2 respectively.